Imagine waking to a bright, sunny day, but not really being able to see. Some people go their whole lives without witnessing that vivid red ball from their youth or the facial features of a loved one. Kristina Narfström, a veterinary ophthalmologist at the University of Missouri, is doing research that promises to provide some light at the end of the tunnel.
Genetic transfer can be used to replace dead photoreceptor cells. Narfström employs this method to correct protein defects in the eyes. The procedure involves injecting a construct – a vehicle that brings the protein the correct DNA – into the retina cell. The construct is then transported into the nucleus, where it is translated to make the correct protein.